The infestation is usually controlled by chemicals, such as praziquantel (Schmahl and Mehlhorn,
1985; Stetter et al., 2003), mebendazole (Buchmann et al., 1995), quinaldine (Crigel et al., 1995) and
toltrazuril (Schmahl and Mehlhorn, 1988). In China, praziquantel and mebendazole are commonly used.
國外常用的治療指環蟲的化學藥物有：吡喹酮，甲苯咪唑，喹哪啶，甲苯三嗪酮；我國常用的是吡喹酮，甲苯咪唑。
Cumulative doses up to 10 mg praziquantel/l water were tolerated without side-effects by Angel Fish (Pterophyllum scalare), Discus, and a variety of catfish species (Ancistrus sp., Corydoras sp.). It was found appropriate to start with a dosage of 2.5 mg/l and to add the same dosage every other day several times. All adult parasites and larvae were killed by this treatment. For the complete elimination of the Dactylogyridae-population in a closed aquarium system, 3 therapy-cycles (duration: 5-6 d, accumulated dosage: 2.5 mg/l/d) prooved to be effective. It was important to interrupt the therapy-cycles with intervals without medication (1 to 4 weeks).
在不換水的養殖系統中，吡喹酮浸泡，濃度2.5g/立方米，隔一天用一次，連續使用3次可以殺滅所有的指環蟲。
不過別人是針對熱帶觀賞魚，此方法僅供參考。
